I'm a surgeon-scientist asking how far we can slow, and one day reverse, the ageing of the body, starting with bone, muscle, and joint. My work runs from clinic to lab: orthopaedic and sports surgery, the biology of osteoarthritis, sarcopenia and osteoporosis, the cardiometabolic side of ageing, and the tools to intervene: immunomodulatory biomaterials, nanoparticle drug delivery, and AI-guided surgery.
Why it matters: chemokines, the HYBID enzyme, and failing lymphatic drainage turn a worn joint into a self-sustaining fire, find the loop, and you can break it.
Why it matters: inflammatory fat accelerates muscle loss with age, and everyday physical activity measurably slows decline and lowers mortality.
Why it matters: the same inflammaging that stiffens a joint stiffens the heart, visceral adiposity, hypertension, and ventricular hypertrophy in postmenopausal women.
Why it matters: turning the biology into tools, nanoparticle and aptamer carriers that target repair to bone and joint, and the AI, robotics, and VR reshaping how surgery is planned, performed, and rehabilitated.
An international, peer-reviewed medical journal I founded and edit, published on its own independent site. Bilingual, with four reader layers per article, and no article processing charges.
Osteoarthritis is the world's most common joint disease and one of its most stubborn, partly because cartilage, once gone, doesn't really grow back. A tour of what's happening inside an aching joint, and where the new generation of treatments fits in.
Read the essay →Muscle loss with age, sarcopenia, is part inevitable, mostly modifiable. What the population data, including our own umbrella review, says really works, and what doesn't.
Read →What to eat, what to ask, what the surgical team is doing while you sleep. A short, honest guide for the evening before an operation, written by someone who has stood on both sides of the door.
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